Biotechnology

What is Biotechnology?

Biotechnology is a major branch of life sciences that focuses on manipulating living organism and biological systems with the intent to create or modify products for specific use. Biotechnology uses a broad range of biology discipline such as genetics, biochemistry, molecular biology and so on. Biotechnology is used across a diversified range of applications, including medicine, agriculture, industrial, and environmental.

HORIBA offers a large choice of innovative technologies such as steady state and lifetime fluorescence, X-Ray fluorescence, particle size analysis and Zeta potential analysis to support a wide range of biotechnology applications.

Browse Applications

Quantitative Analysis of Low-concentration Hydrogen Content in Titanium Alloy
Can we perform quantitative analysis of hydrogen in a titanium alloy to prevent hydrogen embrittlement?
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Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
Production of a single domain antibody Q17c directed against recombinant HER2 protein and its binding study by Surface Plasmon Resonance imaging technology
This application note shows how binding kinetics of single-domain antibodies can be studied with SPRi technology. QVQ produces single-domain antibodies from camelids (sdAbs or VHH). Like conventional Abs, sdAbs are able to bind specific epitopes with high binding affinity. The small size of sdAbs allows for enhanced tumor penetration and fast blood clearance, features that are favorable for in vivo imaging applications. Here, the binding of the anti-HER2 sdAb Q17c to recombinant HER2 protein was assessed using Surface Plasmon Resonance imaging (SPRi). An optimization of immobilization conditions was performed for Q17c and its specific antigen HER2 using a single SPRi-Biochip.
Read more
Elemental micro-analysis of leaves using EDXRF
Calcium micro-nodules are identified within mulberry leaves, and XRF mapped imaging provides a correlation between nodule concentration and leaf age. In a seperate study, the uptake of heavy element pollutants by plants is investigated, with high resolution images quickly acquired to show the distribution of lead through the leaf.
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Biological applications of XRF microscopy
The effect of zinc on gastric ulcer healing has been investigated - mapped imaging of tissue samples shows evidence of zinc accumulation within the ulcerated tissue. In a separate study a fish otolith ('ear bone') has been analysed to reveal its heterogeneous elemental composition and physical structure.
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High Throughput Screening of Affimer Proteins using SPRi Label-Free Technology
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Monitoring Whole Leaf Fluorescence Using Time‐resolved Techniques
Light incident on a leaf can be absorbed by chlorophyll to commence the photosynthetic cycle. Excess energy can be liberated as heat or by emission of fluorescence and this can be used to assess the efficiency of the photosynthetic process.
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Stopped flow time‐resolved fluorescence study of serum albumin – curcuminoid binding
Rapid mixing accessories to perform stopped flow measurements have found application in characterizing interactions and reactions occurring in solution. Reactants are expelled from syringes, mixed and injected into a flowcell.
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Dye‐protein binding monitored in a microliter volume using timeresolved fluorescence
The potential health benefits stemming from the antioxidant activity of curcumin, commonly found in turmeric (Curcuma longa L), has attracted the interest of several research groups.
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Analytical Chemistry in Biotechnology
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Browse Products

9480-10C Long ToupH electrode (for large containers and long test tubes)
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5402 DO Electrode Tip
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9481-10C Sleeve ToupH electrode (for viscous and non-aqueous samples)
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Chloride ion electrode tip 7660S
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Fluoride ion electrode (combination) 6561S-10C
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9418-10C Micro ToupH electrode (for low-volume samples)
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NIST pH Buffer Solution Kit
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Fluoride ion electrode tip 7661S
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Ammonia electrode (combination) 5002S-10C
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9415-10C Standard ToupH electrode (for general laboratory application)
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LAQUA PH1300
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Benchtop Water Quality Meters

USA pH Buffer Solution Kit
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LAQUAtwin pH-33
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Pocket Water Quality Meters

9520-10D DO electrode
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Ammonia electrode membrane caps
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LAQUA PH1200
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Benchtop Water Quality Meters

pH 1.68 Buffer Solution
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LAQUAtwin pH-22
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Pocket Water Quality Meters

7541 DO Electrode Tip
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3551-10D Conductivity Cell (Submersible Type)
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Nitrate ion electrode (combination) 6581S-10C
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LAQUA PH1100
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Benchtop Water Quality Meters

pH 4.01 Buffer Solution
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LAQUAtwin pH-11
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Pocket Water Quality Meters

Nitrate ion electrode tip 7681S
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Potassium ion electrode (combination) 6582S-10C
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LAQUAtwin Ca-11
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Pocket Water Quality Meters

LAQUA EC1100
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Benchtop Water Quality Meters

9615S-10D Standard ToupH electrode (for general laboratory application)
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pH 6.86 Buffer Solution
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9551-20D DO Electrode
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3552-10D Conductivity Cell (Submersible Type)
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Reference Electrode 2060A-10T
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Standard type

Potassium ion electrode tip 7682S
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9551-100D DO Electrode
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XGT-9000
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X-ray Analytical Microscope

LAQUAtwin NO3-11C/NO3-11S/NO3-11
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Pocket Water Quality Meters

LAQUA PC1100
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Benchtop Water Quality Meters

9618S-10D Micro ToupH electrode (for low-volume samples)
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pH 7.00 Buffer Solution
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Powder for ORP Standard Solution 160-51
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5401 DO Electrode Tip
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Reference Electrode 2565A-10T
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Double-junciton type

LAQUA WQ-330-K
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Handheld Water Quality Meters

84 uS/cm Conductivity Standard Solution
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1413 uS/cm Conductivity Standard Solution
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3553-10D Conductivity Cell (Submersible Type)
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100 mg/L Ammonium Ion Standard Solution
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LAQUAtwin K-11
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Pocket Water Quality Meters

LAQUA DS-72
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Benchtop Water Quality Meters

9680S-10D Long ToupH electrode (for large containers and long tubes)
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pH 9.18 Buffer Solution
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pH Sensor S010
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Powder for ORP Standard Solution 160-22
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Temperature Compensation Electrode 4163-10T
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LAQUA WQ-320-K
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Handheld Water Quality Meters

12.88 mS/cm Conductivity Standard Solution
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9382-10D Conductivity Cell (Submersible Type)
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3561-10D Conductivity Cell (Flow Type)
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3562-10D Conductivity Cell (Flow Type)
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1000 mg/L Ammonium Ion Standard Solution
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LAQUAtwin Na-11
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Pocket Water Quality Meters

9681S-10D Sleeve ToupH electrode (for viscous and non-aqueous samples)
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111.8 mS/cm Conductivity Standard Solution
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pH 10.01 Buffer Solution
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LAQUA F-74
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Benchtop Water Quality Meters

Salt electrode S021
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3573-10C Conductivity Cell (Flow Type)
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LAQUA WQ-310-K
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Handheld Water Quality Meters

LO-300
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Laser scanning Oil Film Detector

3574-10C Conductivity Cell (Flow Type)
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Calcium ion electrode tip 7683S
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100 mg/L Calcium Ion Standard Solution
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LAQUAtwin Salt-22
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Pocket Water Quality Meters

pH 12.46 Buffer Solution
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LAQUA F-73
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Benchtop Water Quality Meters

Sodium ion electrode S022
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LAQUA PD220
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Handheld Water Quality Meters

TPNA-500
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Automatic Total Nitrogen/Phosphorus Monitoring

1000 mg/L Calcium Ion Standard Solution
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LAQUAtwin Salt-11
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Pocket Water Quality Meters

LAQUA F-72
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Benchtop Water Quality Meters

Potassium Ion Sensor S030
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9625-10D (for general-purpose use)
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Electrode protector cap (3 pcs/pack)
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LAQUA PD210
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Handheld Water Quality Meters

CODA-500
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Automatic COD Monitor

100 mg/L Chloride Ion Standard Solution
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1000 mg/L Chloride Ion Standard Solution
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LAQUAtwin EC-33
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Pocket Water Quality Meters

9630-10D (for low conductivity samples)
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Nitrate ion electrode S040
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pH Standard Solution 100-2
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LAQUA PC220
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Handheld Water Quality Meters

OPSA-150
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Organic Pollutant Monitor

100 mg/L Fluoride Ion Standard Solution
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LAQUAtwin EC-22
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Pocket Water Quality Meters

9631-10D (for hydrofluoric acid or HF samples)
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Calcium Ion Sensor S050
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pH Standard Solution 100-4
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Printer (for GLP/GMP compliance)
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Cyanide ion electrode 8001-10C
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LAQUA PC210
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Handheld Water Quality Meters

U-50
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Multiparameter Water Quality Checker

1000 mg/L Fluoride Ion Standard Solution
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LAQUAtwin EC-11
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Pocket Water Quality Meters

9632-10D (for strong alkali samples)
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pH Standard Solution 100-7
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Chloride ion electrode 8002-10C
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LAQUA EC220
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Handheld Water Quality Meters

OCMA-550
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Oil Content Analyzer

100 mg/L Nitrate Ion Standard Solution
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[Exclusively for TWIN] Conductivity Cell 0413
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pH Standard Solution 100-9
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6367-10D (for high accuracy pH measurement)
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Sulfide ion electrode 8003-10C
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LAQUA EC210
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Handheld Water Quality Meters

Digital simulator X-51
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Digital simulator X-52
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USB cable
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AC adapter cable set
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1000 mg/L Nitrate Ion Standard Solution
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LCD protection sheet
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[Exclusively for CARDY] Sodium ion electrode 0221
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For the C-121 and C-122

pH Standard Solution 100-10
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6377-10D (for low-conductivity samples and non-aqeous solvents)
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Iodide ion electrode 8004-10C
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LAQUA DO220
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Handheld Water Quality Meters

OCMA-500
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Oil Content Analyzer

Ammonia Ionic Strength Adjustor
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Calcium Ionic Strength Adjustor
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Chloride Ionic Strength Adjustor
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Protection cover
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[Exclusively for CARDY] Potassium ion electrode 0231
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For the C-131

Condensed pH Standard Solution 110-4
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Bromide ion electrode 8005-10C
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6252-10D (for food samples)
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LAQUA DO210
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Handheld Water Quality Meters

Fluoride Ionic Strength Adjustor
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Nitrate Ionic Strength Adjustor
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Potassium Ionic Strength Adjustor
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Ammonia Electrode Filling Solution
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Calcium Electrode Filling Solution
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Chloride Electrode Filling Solution
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Electrode hook for D-70 Series, ES-71, and OM-71
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0040-10D ISFET pH electrode
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Condensed pH Standard Solution 110-7
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Copper ion electrode 8006-10C
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LAQUA PH220
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Handheld Water Quality Meters

Condensed pH Standard Solution 110-10
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Cadmium ion electrode 8007-10C
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LAQUA PH210
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Handheld Water Quality Meters

Glass Electrode 1066A-10C
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Standard type

Glass Electrode 1076A-10C
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For measurement of low-conductivity water and non-aqueous solvents.

FA-70A Integrated Electrode Stand
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6069-10C (for very slender test tubes)
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Powder for pH Standard Solution 150-4
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Lead ion electrode 8008-10C
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6261-10C (for flat surface measurement)
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LAQUAact PH130
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Handheld Water Quality Meters

FA-70S Electrode stand (adjustable type)
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Powder for pH Standard Solution 150-7
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Thiocyanate ion electrode 8009-10C
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LAQUAact PH120
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Handheld Water Quality Meters

Powder for pH Standard Solution 150-9
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DP-50S Electrode stand
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Fluoride ion electrode 8010-10C
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LAQUAact PH110
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Handheld Water Quality Meters

DP-70S Electrode Stand
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Silver ion electrode 8011-10C
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LAQUAact EC120
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Handheld Water Quality Meters

Sodium ion electrode 1512A-10C
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LAQUAact EC110
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Handheld Water Quality Meters

Nitrate ion electrode 8201-10C
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Nitrate Electrode Filling Solution
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LAQUAact DO120
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Handheld Water Quality Meters

Potassium ion electrode 8202-10C
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LAQUA 21 CFR Part 11 Software
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LAQUAact DO110
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Handheld Water Quality Meters

Calcium ion electrode 8203-10C
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Potassium Electrode Filling Solution
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LAQUAact PD110
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Handheld Water Quality Meters

LAQUAact PC110
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Handheld Water Quality Meters

ICP Neo
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ICP Software

TDM - The Time-Domain Monochromator
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EMGA-921
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Hydrogen Analyzer

XGT-7200
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X-ray Analytical Microscope

9651-10D (for field testing)
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SPRi-Arrayer
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Direct contact spotting

Ultima
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Ultra Fast TCSPC Lifetime Fluorometer

SpectraLED
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LED Phosphorescence Light Sources

OpenPleX
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Manual label-free molecular interaction analysis machine Flexible Research Platform

XelPleX
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Fully automated label-free molecular interaction analysis machine One System for Molecule Screening & Crude Sample Analysis

DeltaTime
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TCSPC Lifetime Kit

DeltaPro
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TCSPC Lifetime Fluorometer

DeltaFlex
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TCSPC Lifetime Fluorometer

XploRA INV
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Inverted Raman Microscope

Aqualog
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Water Treatment Plant Analyzer

HQ-300
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Water Quality Meter with HART communication

HR-200 (Four-Wire Analyzer)
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Industrial residual ch analyzer

HE-300C
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Industrial electric conductivity meter (Two-Wire Transmitter)

HP-300
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Industrial pH meter (Two-Wire Transmitter)

HE-200C
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Industrial electric conductivity meter (Four-Wire Analyzer)

HP-200
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Industrial pH meter (Four-Wire Analyzer)

HR-480 (The Slim48 series)
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Industrial residual chlorine meter

HE-480C
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Industrial conductivity meter (low concentration type)

Industrial pH meter four-point alarm and a time sharing proportional control HP-960FTP
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HP-480TP
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Industrial pH meter - Industrial time sharing proportional control

HP-480PL
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Industrial pH meter - Pulse poportional control

HP-480
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Industrial pH meter

HC-200NH
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Ammonia Nitrogen Meter

HD-200FL
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Industrial dissolved oxygen analyzer (Four-Wire Analyzer)

HU-200SS
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Industrial MLSS meter (Four-Wire Analyzer)

HD-300
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Industrial dissolved oxygen analyzer (Two-Wire Transmitter)

HO-300 (Two-Wire Transmitter)
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Industrial ORP meter

HE-200H (Four-Wire Analyzer)
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Industrial electric conductivity meter

HD-200
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Industrial dissolved oxygen analyzer (Four-Wire Analyzer)

HO-200
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Industrial ORP meter (Four-Wire Analyzer)

HE-960HI
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Sanitary Conductivity Meter (Wide-range type)

HD-480
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Industrial dissolved oxygen analyzer (The Slim48 series)

HE-960CW
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2-channel Sanitary Conductivity Meter (Low Concentration type)

HE-480H
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Industrial conductivity meter (high concentration type)

HO-480
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Industrial ORP meter

HP-200-K (Four-Wire Analyzer)
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Industrial pH meter

PM-960
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Converter for peracetic acid monitor

HE-300R
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Industrial electric resistivity meter (Two-Wire Transmitter)

HT-110
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Pharmaceutical Total Organic Carbon Monitor - Online TOC-Analyzer

HE-960RW
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Industrial resistivity meter

HE-480R
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Industrial resistivity meter

Sanitary Conductivity Sensor (Ferrule Clamp type) FES-210L
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Insertion sensor type for wide-range conductivity meter HE-960HI

FES-310L
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Sanitary Conductivity Sensor (Flow Through type)

ESH-01-C-SN
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Sanitary Conductivity Sensor (Ferrule Clamp type) for Low Concentrations

FS-01FC-SL Series
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Sanitary Conductivity Sensor (Flow Through type) for Low Concentrations